Cornoid Lamella is indicative of DSAP
Here I found (on another website) some information that relates to diagnosing DSAP (a form of porokeratosis). I am uncertain if this lab test differentiates DSAP from Actinic Keratosis. I assume that it does. Any help on this topic would be helpful.
Histologic Findings: The
cornoid lamella is the histopathologic hallmark of all forms of porokeratosis.
It is essential that the specimen be taken from the peripheral, raised,
hyperkeratotic ridge to demonstrate this finding. The cornoid lamella consists
of a thin column of tightly packed parakeratotic cells within a keratin-filled
epidermal invagination. The parakeratotic column extends at an angle away from
the center of the lesion and develops from interfollicular epidermis but may
involve the ostia of hair follicles or sweat ducts. Within the parakeratotic
column the horny cells appear homogeneous and possess deeply basophilic pyknotic
nuclei. In the epidermis beneath the parakeratotic column the keratinocytes are
irregularly arranged and have pyknotic nuclei with perinuclear edema. No
granular layer is seen within the parakeratotic column, while the keratin-filled
invagination of the epidermis has a well-developed granular layer. The papillary
dermis beneath the cornoid lamella contains a moderately dense lymphocytic
infiltrate and dilated capillaries.
Note that DSAP can and may be diagnosed without doing this lab test. A good doctor will be able to positively identify DSAP visually.
LINKS
The 5 layers of the epidermis - Skin basics.